Post by rabia373 on Mar 11, 2024 4:26:06 GMT
Home \ News \ Growth hormone blockade stimulates weight loss Growth hormone blockade stimulates weight loss May , Published in:News Discovery of the Institute of Biomedical Sciences sets a precedent for studies on new treatments for obesity Discovery of the Institute of Biomedical Sciences sets a precedent for studies on new treatments for obesity Growth hormone (GH) is also responsible for activating a group of hypothalamic neurons called AgRP, which control food intake and energy expenditure – Photo: Marcos Santos/USP Images Growth hormone (GH) is produced by the pituitary gland and is responsible for regulating height and bone growth. However, a discovery by USP’s Institute of Biomedical Sciences (ICB) may not only make this hormone to have its name altered, but also require updating of physiology didactic textbooks. It is due to the fact that scientists have found GH as also responsible for activating a group of hypothalamic neurons called AgRP, which control food intake and energy expenditure. In the experiments with mice, because of food deprivation, the control group animals’ organisms underwent a series of metabolic and endocrine alterations to save energy. Animals without GH receptors in AgRP neurons did not enter this “economic mode” and thus have lost more weight and body fat.
These findings set a precedent for GH blockade to be therapeutically useful in treating obesity. “In the long term, our findings may stimulate further research into the development of compounds or drugs aimed to optimize weight loss,” it was explained by Professor José Donato Júnior, from the Department of Physiology and Biophysics, one of the authors of the study. The data are described in the paper Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons, publis Whatsapp Number List hed in early February on the multidisciplinary science journal Nature Communications, and whose first author is the researcher Isadora C. Furigo. “We have found that over % AgRP neurons express GH receptors,” Donato Junior stated. Feeling hungry is a sensation that comes from signals emitted by the brain, which knows that the person has not eaten because of a signal that was sent to it by some hormone: GH is that signal. GH is like a siren that the body activates and is heard by AgRP neurons, since they have receptors for this hormone. And GH, acting on these neurons, coordinates all bodily adaptations aimed at energy saving.
The Professor explained that a paper published in the s on Science Magazine had already shown that GH is highly secreted when we are in food deprivation. To act on body growth, GH secretion must have a pulsatile pattern, that is, it has to be secreted in pulses over time. With food deprivation, GH is secreted continuously, but this new pattern prevents the hormone from acting to stimulate growth. But, then, why does the body produce GH during food deprivation? Researchers have found that GH, by activating AgRP neurons during food deprivation, stimulates the “economic mode” of the body by decreasing both the secretion of thyroid hormones and the metabolism – Photo: Marcos Santos/USP Images This was a question that scientists could not explain so far. The study has provided answers to this questioning: ICB’s researchers have found that GH, by activating AgRP neurons during food deprivation, stimulates the “economic mode” of the organism by decreasing both the thyroid hormone secretion and the metabolism. “That’s why it’s so difficult to lose weight: the body adapts to the situation,” Donato Júnior.
These findings set a precedent for GH blockade to be therapeutically useful in treating obesity. “In the long term, our findings may stimulate further research into the development of compounds or drugs aimed to optimize weight loss,” it was explained by Professor José Donato Júnior, from the Department of Physiology and Biophysics, one of the authors of the study. The data are described in the paper Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons, publis Whatsapp Number List hed in early February on the multidisciplinary science journal Nature Communications, and whose first author is the researcher Isadora C. Furigo. “We have found that over % AgRP neurons express GH receptors,” Donato Junior stated. Feeling hungry is a sensation that comes from signals emitted by the brain, which knows that the person has not eaten because of a signal that was sent to it by some hormone: GH is that signal. GH is like a siren that the body activates and is heard by AgRP neurons, since they have receptors for this hormone. And GH, acting on these neurons, coordinates all bodily adaptations aimed at energy saving.
The Professor explained that a paper published in the s on Science Magazine had already shown that GH is highly secreted when we are in food deprivation. To act on body growth, GH secretion must have a pulsatile pattern, that is, it has to be secreted in pulses over time. With food deprivation, GH is secreted continuously, but this new pattern prevents the hormone from acting to stimulate growth. But, then, why does the body produce GH during food deprivation? Researchers have found that GH, by activating AgRP neurons during food deprivation, stimulates the “economic mode” of the body by decreasing both the secretion of thyroid hormones and the metabolism – Photo: Marcos Santos/USP Images This was a question that scientists could not explain so far. The study has provided answers to this questioning: ICB’s researchers have found that GH, by activating AgRP neurons during food deprivation, stimulates the “economic mode” of the organism by decreasing both the thyroid hormone secretion and the metabolism. “That’s why it’s so difficult to lose weight: the body adapts to the situation,” Donato Júnior.